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A small quantity of anesthetic may be instilled into the joint. Consult your pharmacist for more information. Late-onset asthma is less prevalent as compared to early-onset asthma and patients with this type of asthma frequently present with atypical symptoms and fixed airflow limitation instead of reversible bronchoconstriction. No Study Results Posted. The half-life may be prolonged two-fold or more in patients with liver actonide.